{"id":4048,"date":"2021-07-19T23:40:54","date_gmt":"2021-07-19T23:40:54","guid":{"rendered":"https:\/\/curesz.org\/?page_id=4048"},"modified":"2023-11-15T14:18:23","modified_gmt":"2023-11-15T19:18:23","slug":"tardive-dyskinesia-more-than-a-side-effect-2","status":"publish","type":"page","link":"https:\/\/curesz.org\/he\/tardive-dyskinesia-more-than-a-side-effect-2\/","title":{"rendered":"\u05d3\u05d9\u05e1\u05e7\u05d9\u05e0\u05d6\u05d9\u05d4 \u05d8\u05e8\u05d3\u05d9\u05d1\u05d9\u05ea: \u05d9\u05d5\u05ea\u05e8 \u05de\u05ea\u05d5\u05e4\u05e2\u05ea \u05dc\u05d5\u05d5\u05d0\u05d9"},"content":{"rendered":"

<\/span><\/div>

\u05d3"\u05e8 \u05e7\u05e8\u05d9\u05d9\u05d2 \u05e6'\u05e4\u05e7\u05d4<\/a>, \u05d7\u05d1\u05e8, \u05de\u05d5\u05e2\u05e6\u05ea \u05d4\u05de\u05e0\u05d4\u05dc\u05d9\u05dd, \u05e7\u05e8\u05df CURESZ, \u05e4\u05e1\u05d9\u05db\u05d9\u05d0\u05d8\u05e8 \u05e4\u05e8\u05d8\u05d9 \u05d5\u05e2\u05d5\u05d6\u05e8 \u05e4\u05e8\u05d5\u05e4\u05e1\u05d5\u05e8 \u05dc\u05e4\u05e1\u05d9\u05db\u05d9\u05d0\u05d8\u05e8\u05d9\u05d4, \u05d1\u05d9\u05ea \u05d4\u05e1\u05e4\u05e8 \u05dc\u05e8\u05e4\u05d5\u05d0\u05d4 \u05e9\u05dc \u05d0\u05d5\u05e0\u05d9\u05d1\u05e8\u05e1\u05d9\u05d8\u05ea \u05e6\u05e4\u05d5\u05df \u05e7\u05e8\u05d5\u05dc\u05d9\u05d9\u05e0\u05d4<\/p>\n<\/div><\/div><\/div>

Tardive Dyskinesia (TD) was \ufb01rst described in the early 1960s, but we don\u2019t have a clear understanding of why it happens despite nearly 60 years of research. TD does seem to have a clear relationship with dopamine, which regulates a vast number of functions in our bodies, including attention, pleasure- seeking, and motor function. Some psychiatric disorders, including disturbances of mood, sensory perception, and thought processes are believed to be associated with an excess of dopamine stimulation in certain pathways, or \u201ccircuits\u201d of the brain.<\/p>\n

\u05dc\u05e2\u05ea\u05d9\u05dd \u05e7\u05e8\u05d5\u05d1\u05d5\u05ea \u05d0\u05e0\u05d5 \u05de\u05e9\u05ea\u05de\u05e9\u05d9\u05dd \u05d1\u05ea\u05e8\u05d5\u05e4\u05d5\u05ea \u05d0\u05e0\u05d8\u05d9-\u05e4\u05e1\u05d9\u05db\u05d5\u05d8\u05d9\u05d5\u05ea \u05dc\u05ea\u05e1\u05de\u05d9\u05e0\u05d9\u05dd \u05d0\u05dc\u05d5 \u05de\u05db\u05d9\u05d5\u05d5\u05df \u05e9\u05d4\u05dd \u05d7\u05d5\u05e1\u05de\u05d9 \u05e7\u05d5\u05dc\u05d8\u05e0\u05d9 \u05d3\u05d5\u05e4\u05de\u05d9\u05df (DRB), \u05d5\u05d1\u05db\u05da \u05de\u05d5\u05e0\u05e2\u05d9\u05dd \u05de\u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05dc\u05d4\u05e9\u05dc\u05d9\u05dd \u05d0\u05ea \u05d4\u05de\u05e2\u05d2\u05dc. \u05d1\u05de\u05e2\u05d2\u05dc\u05d9 \u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05d4\u05d9\u05e4\u05e8\u05d0\u05e7\u05d8\u05d9\u05d1\u05d9\u05d9\u05dd, \u05d6\u05d4 \u05de\u05e0\u05e8\u05de\u05dc \u05d0\u05ea \u05d4\u05ea\u05e4\u05e7\u05d5\u05d3, \u05d0\u05da DRBs \u05d0\u05d9\u05e0\u05dd \u05de\u05e1\u05d5\u05d2\u05dc\u05d9\u05dd \u05dc\u05d4\u05d1\u05d7\u05d9\u05df \u05d1\u05d9\u05df \u05de\u05e1\u05dc\u05d5\u05dc\u05d9 \u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05e4\u05e2\u05d9\u05dc\u05d9\u05dd \u05d9\u05ea\u05e8 \u05e2\u05dc \u05d4\u05de\u05d9\u05d3\u05d4 \u05dc\u05d1\u05d9\u05df \u05de\u05e1\u05dc\u05d5\u05dc\u05d9 \u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05e0\u05d5\u05e8\u05de\u05dc\u05d9\u05d9\u05dd. \u05dc\u05e4\u05e2\u05de\u05d9\u05dd \u05d7\u05e1\u05d9\u05de\u05ea \u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05d9\u05db\u05d5\u05dc\u05d4 \u05dc\u05d4\u05e4\u05d7\u05d9\u05ea \u05d0\u05ea \u05d4\u05ea\u05e4\u05e7\u05d5\u05d3 \u05d1\u05de\u05e1\u05dc\u05d5\u05dc\u05d9\u05dd \u05e9\u05d0\u05e1\u05d5\u05e8 \u05dc\u05d4\u05dd, \u05d5\u05dc\u05d2\u05e8\u05d5\u05dd \u05dc\u05ea\u05d5\u05e6\u05d0\u05d5\u05ea \u05dc\u05d0 \u05de\u05db\u05d5\u05d5\u05e0\u05d5\u05ea.<\/p>\n

\u05d4\u05d2\u05e8\u05e2\u05d9\u05e0\u05d9\u05dd \u05d4\u05d1\u05e1\u05d9\u05e1\u05d9\u05d9\u05dd \u05d4\u05dd \u05d4\u05d7\u05dc\u05e7 \u05d1\u05de\u05d5\u05d7 \u05e9\u05d0\u05d7\u05e8\u05d0\u05d9 \u05e2\u05dc \u05e9\u05dc\u05d9\u05d8\u05d4 \u05d1\u05ea\u05e0\u05d5\u05e2\u05d5\u05ea, \u05d5\u05d4\u05d5\u05d0 \u05ea\u05dc\u05d5\u05d9 \u05d2\u05dd \u05d1\u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05db\u05d3\u05d9 \u05dc\u05e0\u05d4\u05dc \u05d0\u05ea \u05d4\u05d0\u05d9\u05ea\u05d5\u05ea \u05e9\u05dc\u05d5. \u05e9\u05d9\u05de\u05d5\u05e9 \u05de\u05de\u05d5\u05e9\u05da \u05d1-DRBs \u05d9\u05db\u05d5\u05dc \u05dc\u05e2\u05d5\u05e8\u05e8 \u05d0\u05ea \u05d4\u05d2\u05e8\u05e2\u05d9\u05e0\u05d9\u05dd \u05d4\u05d1\u05e1\u05d9\u05e1\u05d9\u05d9\u05dd \u05dc\u05d9\u05d9\u05e6\u05e8 \u05d9\u05d5\u05ea\u05e8 \u05de\u05d3\u05d9 \u05e7\u05d5\u05dc\u05d8\u05e0\u05d9 \u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05e8\u05d2\u05d9\u05e9\u05d9\u05dd \u05d1\u05de\u05d9\u05d5\u05d7\u05d3. \u05d1\u05e0\u05d9\u05e1\u05d9\u05d5\u05df \u05dc\u05d0\u05d6\u05df \u05de\u05d7\u05d3\u05e9 \u05d0\u05ea \u05d0\u05d5\u05ea\u05d5\u05ea \u05d4\u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05d4\u05de\u05d5\u05e4\u05d7\u05ea\u05d9\u05dd \u05e9\u05dc\u05d5, \u05d4\u05ea\u05d4\u05dc\u05d9\u05da \u05e2\u05e9\u05d5\u05d9 \u05dc\u05e4\u05e6\u05d5\u05ea \u05d9\u05ea\u05e8 \u05e2\u05dc \u05d4\u05de\u05d9\u05d3\u05d4 \u05e2\u05d1\u05d5\u05e8 \u05d7\u05dc\u05e7\u05dd. \u05d4\u05de\u05e2\u05e8\u05db\u05ea \u05d4\u05de\u05d5\u05d8\u05d5\u05e8\u05d9\u05ea \u05d4\u05d5\u05e4\u05db\u05ea \u05dc\u05d4\u05d9\u05d5\u05ea \u05e8\u05d2\u05d9\u05e9\u05d4 \u05d9\u05ea\u05e8, \u05d5\u05d3\u05d5\u05e4\u05de\u05d9\u05df \u05db\u05e2\u05ea \u05de\u05d2\u05e8\u05d4 \u05d0\u05d5\u05ea\u05d4 \u05d9\u05ea\u05e8 \u05e2\u05dc \u05d4\u05de\u05d9\u05d3\u05d4, \u05d5\u05db\u05ea\u05d5\u05e6\u05d0\u05d4 \u05de\u05db\u05da \u05d4\u05ea\u05e0\u05d5\u05e2\u05d5\u05ea \u05d4\u05d1\u05dc\u05ea\u05d9 \u05e8\u05e6\u05d5\u05e0\u05d9\u05d5\u05ea, \u05d0\u05d5 "\u05d3\u05d9\u05e1\u05e7\u05d9\u05e0\u05d6\u05d9\u05d4" \u05e9\u05e0\u05d5\u05ea\u05e0\u05d5\u05ea \u05dc-TD \u05d0\u05ea \u05e9\u05de\u05d5. "Tardive" \u05de\u05d2\u05d9\u05e2 \u05de\u05d4\u05de\u05d9\u05dc\u05d4 \u05d4\u05e6\u05e8\u05e4\u05ea\u05d9\u05ea \u05dc"\u05de\u05d0\u05d5\u05d7\u05e8" \u05de\u05db\u05d9\u05d5\u05d5\u05df \u05e9\u05d1\u05d3\u05e8\u05da \u05db\u05dc\u05dc \u05dc\u05d5\u05e7\u05d7 \u05d7\u05d5\u05d3\u05e9\u05d9\u05dd \u05d0\u05d5 \u05e9\u05e0\u05d9\u05dd \u05e9\u05dc \u05d7\u05e9\u05d9\u05e4\u05d4 \u05dc-DRB \u05dc\u05e4\u05e0\u05d9 \u05e9\u05d4\u05e1\u05d9\u05de\u05e4\u05d8\u05d5\u05de\u05d9\u05dd \u05de\u05ea\u05e4\u05ea\u05d7\u05d9\u05dd.<\/p>\n

\u05ea\u05d0\u05e8 \u05dc\u05e2\u05e6\u05de\u05da \u05e9\u05d0\u05ea\u05d4 \u05de\u05d0\u05d6\u05d9\u05df \u05dc\u05de\u05d5\u05d6\u05d9\u05e7\u05d4 \u05e2\u05dd \u05d7\u05d1\u05e8, \u05d5\u05d0\u05ea\u05d4 \u05d7\u05d5\u05e9\u05d1 \u05e9\u05e2\u05d5\u05e6\u05de\u05ea \u05d4\u05e7\u05d5\u05dc \u05ea\u05e7\u05d9\u05e0\u05d4, \u05d0\u05d1\u05dc \u05d4\u05d9\u05d0 \u05d7\u05d6\u05e7\u05d4 \u05de\u05d3\u05d9 \u05e2\u05d1\u05d5\u05e8\u05d5. \u05d4\u05d5\u05d0 \u05de\u05d5\u05e6\u05d9\u05d0 \u05d0\u05d8\u05de\u05d9 \u05d0\u05d5\u05d6\u05e0\u05d9\u05d9\u05dd, \u05d0\u05d1\u05dc \u05de\u05db\u05e0\u05d9\u05e1 \u05d0\u05d5\u05ea\u05dd \u05dc\u05d0\u05d5\u05d6\u05e0\u05d9\u05d9\u05dd \u05e9\u05dc\u05da \u05d5\u05d2\u05dd \u05dc\u05d0\u05d5\u05d6\u05e0\u05d9\u05d9\u05dd \u05e9\u05dc\u05d5. \u05e2\u05db\u05e9\u05d9\u05d5 \u05d0\u05ea\u05d4 \u05dc\u05d0 \u05d9\u05db\u05d5\u05dc \u05dc\u05e9\u05de\u05d5\u05e2 \u05d0\u05ea \u05d4\u05de\u05d5\u05d6\u05d9\u05e7\u05d4 \u05d1\u05db\u05dc\u05dc, \u05d5\u05d0\u05ea\u05d4 \u05de\u05d2\u05dc\u05d4 \u05e9\u05d0\u05d8\u05de\u05d9 \u05d4\u05d0\u05d5\u05d6\u05e0\u05d9\u05d9\u05dd \u05dc\u05d0 \u05d9\u05d9\u05e6\u05d0\u05d5 \u05d4\u05d7\u05d5\u05e6\u05d4, \u05d0\u05d6 \u05d0\u05ea\u05d4 \u05de\u05d2\u05d1\u05d9\u05e8 \u05d0\u05ea \u05e2\u05d5\u05e6\u05de\u05ea \u05d4\u05e7\u05d5\u05dc \u05db\u05d3\u05d9 \u05dc\u05e4\u05e6\u05d5\u05ea. \u05d1\u05e1\u05d5\u05e4\u05d5 \u05e9\u05dc \u05d3\u05d1\u05e8 \u05d0\u05d8\u05de\u05d9 \u05d4\u05d0\u05d5\u05d6\u05e0\u05d9\u05d9\u05dd \u05e2\u05dc\u05d5\u05dc\u05d9\u05dd \u05dc\u05d4\u05ea\u05e7\u05dc\u05e7\u05dc \u05d5\u05dc\u05e0\u05e9\u05d5\u05e8, \u05d5\u05d4\u05de\u05d5\u05d6\u05d9\u05e7\u05d4 \u05e0\u05e9\u05de\u05e2\u05ea \u05d1\u05e2\u05d5\u05e6\u05de\u05d4 \u05d1\u05dc\u05ea\u05d9 \u05e0\u05e1\u05d1\u05dc\u05ea. \u05dc\u05de\u05e8\u05d1\u05d4 \u05d4\u05e6\u05e2\u05e8, \u05d0\u05ea\u05d4 \u05de\u05d2\u05dc\u05d4 \u05e9\u05db\u05e4\u05ea\u05d5\u05e8 \u05e2\u05d5\u05e6\u05de\u05ea \u05d4\u05e7\u05d5\u05dc \u05e9\u05d1\u05d5\u05e8, \u05d5\u05d0\u05d9 \u05d0\u05e4\u05e9\u05e8 \u05dc\u05d4\u05e0\u05de\u05d9\u05da \u05d0\u05d5\u05ea\u05d5.<\/p>\n

The real problem with TD isn\u2019t that it can develop long after the start of a DRB, it’s that\u00a0it\u2019s generally irreversible. Not everyone taking a DRB gets TD, but those who do can\u2019t get rid of it by stopping the medication. While some risk factors are known, we don\u2019t yet have a very good way of predicting who is going to get it before it happens. Or in the terms of the analogy above, we don\u2019t know whose earplugs are going to malfunction.<\/p>\n

Therefore, we shouldn\u2019t consider TD a \u201cside effect\u201d of DRBs, because side effects go away if you remove the medication that cause them. Rather, we should think of TD as its own syndrome that is caused by exposure to DRBs in vulnerable people. Just like cigarette smoking causes lung cancer in some people \u2013 those who get cancer don\u2019t go into remission just because they stop smoking. Improving tardive dyskinesia at that point requires its own additional treatment, which I\u2019ll discuss in my\u00a0\u05d4\u05e2\u05de\u05d5\u05d3\u05d4 \u05d4\u05d1\u05d0\u05d4<\/a>.<\/p>\n

<\/h2>\n<\/div><\/div><\/div><\/div><\/div>
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