{"id":4000,"date":"2021-06-23T14:33:58","date_gmt":"2021-06-23T14:33:58","guid":{"rendered":"https:\/\/curesz.org\/?page_id=4000"},"modified":"2021-06-23T14:33:58","modified_gmt":"2021-06-23T14:33:58","slug":"our-path-to-a-new-treatment-for-schizophrenia","status":"publish","type":"page","link":"https:\/\/curesz.org\/zh\/our-path-to-a-new-treatment-for-schizophrenia\/","title":{"rendered":"\u6211\u4eec\u901a\u5f80\u7cbe\u795e\u5206\u88c2\u75c7\u65b0\u7597\u6cd5\u7684\u9053\u8def"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1352px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_4 1_4 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:25%;--awb-margin-top-large:0px;--awb-spacing-right-large:7.68%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:7.68%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element\" style=\"--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\"fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"300\" height=\"266\" title=\"\u53f2\u8482\u592b\u4fdd\u7f57\u535a\u58eb\" src=\"https:\/\/curesz.org\/wp-content\/uploads\/2021\/06\/Steve-Paul-cropped.jpg\" data-orig-src=\"https:\/\/curesz.org\/wp-content\/uploads\/2021\/06\/Steve-Paul-cropped-300x266.jpg\" alt class=\"lazyload img-responsive wp-image-4001\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27701%27%20height%3D%27622%27%20viewBox%3D%270%200%20701%20622%27%3E%3Crect%20width%3D%27701%27%20height%3D%27622%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/curesz.org\/wp-content\/uploads\/2021\/06\/Steve-Paul-cropped-200x177.jpg 200w, https:\/\/curesz.org\/wp-content\/uploads\/2021\/06\/Steve-Paul-cropped-400x355.jpg 400w, https:\/\/curesz.org\/wp-content\/uploads\/2021\/06\/Steve-Paul-cropped-600x532.jpg 600w, https:\/\/curesz.org\/wp-content\/uploads\/2021\/06\/Steve-Paul-cropped.jpg 701w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-text fusion-text-1\"><p><strong>Steve Paul \u535a\u58eb\uff0cKaruna Therapeutics \u9996\u5e2d\u6267\u884c\u5b98\u517c\u8463\u4e8b\u4f1a\u4e3b\u5e2d<\/strong><\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_3_4 3_4 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:75%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.56%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:2.56%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-2\"><p><strong>\u6211\u4eec\u5bfb\u6c42\u7cbe\u795e\u5206\u88c2\u75c7\u5dee\u5f02\u5316\u65b0\u7597\u6cd5\u7684\u9014\u5f84<\/strong><\/p>\n<p>40 \u591a\u5e74\u6765\uff0c\u6211\u4e00\u76f4\u81f4\u529b\u4e8e\u63a8\u8fdb\u4e0e\u4e25\u91cd\u7cbe\u795e\u75be\u75c5\u7684\u75c5\u56e0\u548c\u6cbb\u7597\u76f8\u5173\u7684\u79d1\u5b66\u53d1\u5c55\u3002\u901a\u8fc7\u5728\u5b66\u672f\u754c\u548c\u6574\u4e2a\u751f\u7269\u5236\u836f\u884c\u4e1a\u62c5\u4efb\u591a\u4e2a\u89d2\u8272\uff0c\u6211\u7684\u76ee\u6807\u59cb\u7ec8\u5982\u4e00\uff0c\u5e76\u4e14\u73b0\u5728\u5728 Karuna \u7ee7\u7eed\uff1a\u6539\u53d8\u4e25\u91cd\u7cbe\u795e\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u5728 Karuna \uff0c\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u6211\u4eec\u6b63\u5728\u8fd0\u7528\u6211\u4eec\u5728\u836f\u7269\u53d1\u73b0\u548c\u5f00\u53d1\u65b9\u9762\u7684\u5e7f\u6cdb\u77e5\u8bc6\uff0c\u76ee\u6807\u662f\u4e3a\u60a3\u6709\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u7684\u4eba\u63d0\u4f9b\u53d8\u9769\u6027\u836f\u7269\uff0c\u4ece\u6211\u4eec\u7684\u4e3b\u8981\u5019\u9009\u4ea7\u54c1 KarXT \u5f00\u59cb\u3002<\/p>\n<p>\u6211\u53ef\u4ee5\u76f4\u63a5\u8bc1\u660e\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u751f\u7269\u5236\u836f\u884c\u4e1a\u6700\u5177\u6311\u6218\u6027\u7684\u8ffd\u6c42\u4e4b\u4e00\u662f\u6210\u529f\u5f00\u53d1\u51fa\u9488\u5bf9\u5e38\u89c1\u7cbe\u795e\u75be\u75c5\u548c\u795e\u7ecf\u75be\u75c5\u7684\u9ad8\u6548\u3001\u5b89\u5168\u548c\u8010\u53d7\u6027\u5f3a\u7684\u836f\u7269\u3002\u5f00\u53d1\u80fd\u591f\u51cf\u5c11\u8fd9\u4e9b\u75be\u75c5\u7684\u81f4\u6b8b\u75c7\u72b6\u800c\u4e0d\u4ea7\u751f\u7e41\u91cd\u526f\u4f5c\u7528\u7684\u6cbb\u7597\u65b9\u6cd5\u4e00\u76f4\u662f\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\u7684\u3002<\/p>\n<p>\u4ece 1950 \u5e74\u4ee3\u5f15\u5165\u7684\u7b2c\u4e00\u4ee3\u6216\u201c\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u201d\u5f00\u59cb\uff0c\u6297\u7cbe\u795e\u75c5\u836f\u7269\u5386\u6765\u662f\u6210\u4eba\u7cbe\u795e\u5206\u88c2\u75c7\u6700\u5e38\u7528\u7684\u5904\u65b9\u836f\u3002\u4ed6\u4eec\u7684\u53d1\u73b0\u548c\u53d1\u5c55\u5728\u5f53\u65f6\u88ab\u8ba4\u4e3a\u662f\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7684\u7a81\u7834\uff0c\u4f7f\u60a3\u8005\u80fd\u591f\u5728\u95e8\u8bca\u73af\u5883\u4e2d\u63a5\u53d7\u6cbb\u7597\u548c\u7ba1\u7406\u3002\u73b0\u5728\u5df2\u77e5\u8fd9\u4e9b\u7b2c\u4e00\u4ee3\u7597\u6cd5\u4e3b\u8981\u9488\u5bf9\u7a81\u89e6\u540e\u591a\u5df4\u80fa 2 (D<sub>2<\/sub>) \u53d7\u4f53\uff0c\u8fd9\u662f\u4e00\u79cd\u4e5f\u63a7\u5236\u6b63\u5e38\u8fd0\u52a8\u7684\u53d7\u4f53\u3002\u867d\u7136\u8fd9\u4e9b\u836f\u7269\u660e\u663e\u6539\u5584\u4e86\u5e7b\u89c9\u548c\u5984\u60f3\u7b49\u7cbe\u795e\u75c5\u75c7\u72b6\uff0c\u4f46\u8bb8\u591a\u670d\u7528\u8fd9\u4e9b\u836f\u7269\u7684\u60a3\u8005\u4f1a\u51fa\u73b0\u96be\u4ee5\u5fcd\u53d7\u7684\u526f\u4f5c\u7528\uff0c\u8fd9\u4f7f\u5f97\u4e00\u4e9b\u4eba\u96be\u4ee5\u5fcd\u53d7\u8fd9\u4e9b\u836f\u7269\u3002\u7b2c\u4e8c\u4ee3\u6216\u201c\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u201d\u51fa\u73b0\u4e8e 80 \u5e74\u4ee3\u540e\u671f\uff0c\u4ee5\u6c2f\u6c2e\u5e73\u7684\u7a81\u7834\u6027\u518d\u5f00\u53d1\u5f00\u59cb\u3002\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\uff0c\u4e5f\u9488\u5bf9 D<sub>2<\/sub> \u4e0e\u7b2c\u4e00\u4ee3\u6297\u7cbe\u795e\u75c5\u836f\u76f8\u6bd4\uff0c\u591a\u5df4\u80fa\u53d7\u4f53\u4ee5\u53ca\u8bb8\u591a\u5176\u4ed6\u795e\u7ecf\u9012\u8d28\u53d7\u4f53\u901a\u5e38\u8868\u73b0\u51fa\u8f83\u8f7b\u7684\u8fd0\u52a8\u75c7\u72b6\u526f\u4f5c\u7528\uff0c\u5c3d\u7ba1\u5b58\u5728\u5176\u4ed6\u4e0d\u826f\u53cd\u5e94\uff0c\u4f8b\u5982\u4f53\u91cd\u589e\u52a0\u548c\u76f8\u5173\u7684\u4ee3\u8c22\u53d8\u5316\uff0c\u5305\u62ec\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u548c\u5347\u9ad8\u7684\u80c6\u56fa\u9187\uff0c\u53d8\u5f97\u66f4\u666e\u904d\u4e0e\u8fd9\u4e9b\u65b0\u836f\u6709\u5173\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u867d\u7136\u76ee\u524d\u7684\u6297\u7cbe\u795e\u75c5\u836f\u7269\u53ef\u4ee5\u6709\u6548\u63a7\u5236\u9633\u6027\u75c7\u72b6\uff0c\u4f8b\u5982\u5e7b\u89c9\u3001\u5984\u60f3\u4ee5\u53ca\u7ec4\u7ec7\u548c\u8868\u8fbe\u601d\u60f3\u56f0\u96be\uff0c\u4f46\u5b83\u4eec\u4e0d\u80fd\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u5176\u4ed6\u4e3b\u8981\u75c7\u72b6\uff0c\u4f8b\u5982\u6301\u7eed\u6027\u9634\u6027\u75c7\u72b6\uff08\u4f8b\u5982\uff0c\u96be\u4ee5\u4eab\u53d7\u751f\u6d3b\u548c\u793e\u4f1a\u5b64\u7acb\uff09\u6216\u8ba4\u77e5\u56f0\u96be\uff08\u4f8b\u5982\uff0c\u8bb0\u5fc6\u529b\u3001\u6ce8\u610f\u529b\u548c\u6267\u884c\u529f\u80fd\u7f3a\u9677\uff09\u3002<\/p>\n<p>\u4eca\u5929\u5728 Karuna\uff0c\u6211\u4eec\u6b63\u5728\u5f00\u53d1\u4e00\u79cd\u65b0\u836f\uff0c\u5b83\u6709\u53ef\u80fd\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u5176\u4ed6\u7cbe\u795e\u75c5\u75c7\u72b6\u7a81\u51fa\u548c\u81f4\u6b8b\u7684\u75be\u75c5\u3002\u6211\u4eec\u6f5c\u5728\u7684\u65b0\u7597\u6cd5 KarXT\uff08xanomeline + trospium\uff09\u8bde\u751f\u4e8e\u5bfb\u6c42\u53d8\u9769\u6027\u836f\u7269\u4ee5\u6ee1\u8db3\u60a3\u8005\u9700\u6c42\u7684\u5408\u4f5c\u70ed\u60c5\u3002\u5728\u6211\u548c Eli Lilly \u7684\u56e2\u961f\u5076\u7136\u53d1\u73b0 xanomeline \u7684\u6297\u7cbe\u795e\u75c5\u7279\u6027\u5341\u591a\u5e74\u540e\uff0c\u6211\u7684\u540c\u4e8b Karuna \u7684\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u8fd0\u8425\u5b98 Andrew Miller \u51b3\u5fc3\u627e\u5230\u4e00\u79cd\u65b9\u6cd5\u6765\u5229\u7528 xanomeline \u7684\u6cbb\u7597\u76ca\u5904\u3002\u4ed6\u8bc4\u4f30\u4e86\u8d85\u8fc7 7,000 \u79cd\u5176\u4ed6\u7597\u6cd5\u7684\u53ef\u80fd\u7ec4\u5408\uff0c\u4ee5\u627e\u5230\u4e00\u79cd\u4f18\u5316\u7684\u7ec4\u5408\uff0c\u8fd9\u79cd\u7ec4\u5408\u6709\u53ef\u80fd\u663e\u7740\u589e\u5f3a xanomeline \u7684\u8010\u53d7\u6027\u800c\u4e0d\u964d\u4f4e\u5176\u6297\u7cbe\u795e\u75c5\u7279\u6027\u3002\u4ece\u90a3\u91cc\uff0c\u521b\u5efa\u4e86 KarXT \u7684\u60f3\u6cd5\u3002<\/p>\n<p>Xanomeline \u662f KarXT \u4e2d\u7684\u6d3b\u6027\u6cbb\u7597\u6210\u5206\uff0c\u5b83\u901a\u8fc7\u9776\u5411\u79f0\u4e3a\u201c\u6bd2\u8548\u78b1\u53d7\u4f53\u201d\u7684\u5927\u8111\u53d7\u4f53\u8d77\u4f5c\u7528\u3002\u8fd9\u79cd\u6bd2\u8548\u78b1\u53d7\u4f53\u7684\u4e9a\u578b\u5728\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u75c5\u7406\u751f\u7406\u5b66\u6709\u5173\u7684\u5927\u8111\u533a\u57df\u4e2d\u8868\u8fbe\uff0c\u8868\u660e\u9776\u5411\u8fd9\u4e9b\u53d7\u4f53\u53ef\u4ecb\u5bfc xanomeline \u7684\u6297\u7cbe\u795e\u75c5\u6d3b\u6027\u3002 Trospium 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\u7684\u8fd9\u79cd\u65b0\u4f5c\u7528\u673a\u5236\u53ef\u4ee5\u6cbb\u7597\u7cbe\u795e\u75c5\uff0c\u800c\u4e0d\u4f1a\u4ea7\u751f\u901a\u5e38\u4e0e\u76f4\u63a5\u963b\u65ad\u591a\u5df4\u80fa\u53d7\u4f53\u76f8\u5173\u7684\u526f\u4f5c\u7528\u8d1f\u62c5\u3002\u5982\u679c\u83b7\u5f97 FDA \u7684\u6279\u51c6\uff0cKarXT \u51ed\u501f\u5176\u65b0\u9896\u7684\u6297\u7cbe\u795e\u75c5\u4f5c\u7528\u673a\u5236\uff0c\u6709\u53ef\u80fd\u5f00\u521b\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u65b0\u6cbb\u7597\u8303\u5f0f\u3002<\/p>\n<p>\u5728\u6700\u8fd1\u5b8c\u6210\u7684\u7b2c\u4e8c\u9636\u6bb5\u8bd5\u9a8c\u4e2d\uff0cKarXT \u5728\u63a2\u7d22\u6027\u5206\u6790\u4e2d\u8bc1\u660e\u4e86\u7cbe\u795e\u5206\u88c2\u75c7\u9633\u6027\u548c\u9634\u6027\u75c7\u72b6\u7684\u6539\u5584\uff0c\u4ee5\u53ca\u8ba4\u77e5\u6539\u5584\u7684\u8d8b\u52bf\u3002\u8be5\u8bd5\u9a8c\u62a5\u544a\u7684 KarXT 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