{"id":4424,"date":"2022-06-21T14:26:45","date_gmt":"2022-06-21T14:26:45","guid":{"rendered":"https:\/\/curesz.org\/?page_id=4424"},"modified":"2023-11-15T14:47:48","modified_gmt":"2023-11-15T19:47:48","slug":"2022-07-01-drug-discovery-for-schizophrenia","status":"publish","type":"page","link":"https:\/\/curesz.org\/zh\/2022-07-01-drug-discovery-for-schizophrenia\/","title":{"rendered":"\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u836f\u7269\u53d1\u73b0"},"content":{"rendered":"

<\/span><\/div>

Elizabeth Beam\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u54f2\u5b66\u535a\u58eb\uff08\u5982\u56fe\uff09 <\/strong>
\n\u548c\u533b\u5b66\u535a\u58eb Jacob Ballon<\/strong>
\n\u65af\u5766\u798f\u5927\u5b66\u7cbe\u795e\u75c5\u5b66\u4e0e\u884c\u4e3a\u79d1\u5b66\u7cfb<\/strong><\/p>\n<\/div><\/div><\/div>

\u7cbe\u795e\u5206\u88c2\u75c7\u836f\u7269\u53d1\u73b0\u7684\u5341\u5e74\uff1aTAAR1 \u548c\u6bd2\u8548\u78b1\u6fc0\u52a8\u5242<\/p>\n

\u5c31\u5728\u5341\u591a\u5e74\u524d\uff0c\u51e0\u5bb6\u5927\u578b\u5236\u836f\u516c\u53f8\u51b3\u5b9a\u653e\u5f03\u7cbe\u795e\u5206\u88c2\u75c7\u836f\u7269\u7684\u7814\u53d1\u3002\u8fd9\u4e00\u4e3e\u52a8\u4ee4\u60a3\u8005\u548c\u7814\u7a76\u4eba\u5458\u90fd\u611f\u5230\u6cae\u4e27\uff0c\u56e0\u4e3a\u4ed6\u4eec\u66fe\u591a\u6b21\u542c\u5230\u8fc7\u8fd9\u6837\u7684\u627f\u8bfa\uff1a\u7528\u66f4\u5c11\u7684\u526f\u4f5c\u7528\u63a7\u5236\u66f4\u591a\u7684\u75c7\u72b6\u3002\u90a3\u4e48\uff0c\u5927\u578b\u5236\u836f\u516c\u53f8\u4e3a\u4ec0\u4e48\u8981\u79bb\u5f00\u5462\uff1f\u4e00\u9879\u5927\u89c4\u6a21\u8bd5\u9a8c\u7684\u6570\u636e\u663e\u793a\uff0c\"\u5178\u578b \"\u6297\u7cbe\u795e\u75c5\u836f\u7269\u662f\u5728 20 \u4e16\u7eaa 50 \u5e74\u4ee3\u5076\u7136\u53d1\u73b0\u7684\uff0c\u800c \"\u975e\u5178\u578b \"\u6297\u7cbe\u795e\u75c5\u836f\u7269\u662f\u5728 20 \u4e16\u7eaa 90 \u5e74\u4ee3\u7ecf\u8fc7\u591a\u5e74\u7684\u7814\u7a76\u548c\u8bd5\u9a8c\u540e\u53d1\u5e03\u7684\u3002\u7ed3\u679c\u8bc1\u5b9e\uff0c\"\u975e\u5178\u578b \"\u836f\u7269\u51e0\u4e4e\u6ca1\u6709\u4efb\u4f55\u6539\u5584\u3002\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u836f\u7269\u7684\u6295\u8d44\u8017\u8d44\u5de8\u5927\uff0c\u4f46\u5374\u6ca1\u6709\u5f97\u5230\u56de\u62a5--\u4e5f\u5c31\u662f\u8bf4\uff0c\u8fd8\u6ca1\u6709\u3002<\/p>\n

\u73b0\u5728\u56de\u60f3\u8d77\u6765\uff0c\u524d\u4e24\u7c7b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u5177\u6709\u76f8\u4f3c\u7684\u7597\u6548\u5e76\u4e0d\u592a\u4ee4\u4eba\u60ca\u8bb6\u3002\u5b83\u4eec\u90fd\u901a\u8fc7\u963b\u65ad\u591a\u5df4\u80fa\u53d7\u4f53\u53d1\u6325\u4f5c\u7528\u3002\u5236\u836f\u516c\u53f8\u4f3c\u4e4e\u628a\u591a\u5df4\u80fa\u4f5c\u4e3a\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u9776\u70b9\uff0c\u5c31\u50cf\u4ed6\u4eec\u628a\u8840\u6e05\u7d20\u4f5c\u4e3a\u6cbb\u7597\u6291\u90c1\u75c7\u7684\u9776\u70b9\uff0c\u628a\u4e59\u9170\u80c6\u78b1\u4f5c\u4e3a\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u9776\u70b9\u4e00\u6837\u3002\u6bcf\u4e00\u6b21\u5bf9\u6cbb\u7597\u65b9\u6cd5\u7684\u8ffd\u9010\u90fd\u505c\u6ede\u4e0d\u524d\u3002\u836f\u7269\u53ea\u662f\u51cf\u8f7b\u4e86\u75c7\u72b6\uff0c\u5e76\u4e0d\u610f\u5473\u7740\u5b83\u6cbb\u7597\u4e86\u75be\u75c5\u7684\u6f5c\u5728\u75c5\u7406\u751f\u7406\u5b66\u3002\u8bd5\u60f3\u4e00\u4e0b\uff0c\u75c7\u72b6\u662f\u5927\u8111\u4e2d\u7684\u4e00\u56e2\u706b\uff0c\u836f\u7269\u50cf\u6c34\u4e00\u6837\u53ef\u4ee5\u6d47\u706d\u706b\u7130\uff0c\u4f46\u5374\u65e0\u6cd5\u51b7\u5374\u70ed\u7a7a\u6c14\u6216\u963b\u6b62\u6700\u521d\u7684\u706b\u661f\u590d\u71c3\u3002<\/p>\n

\u7136\u800c\uff0c\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u901a\u8fc7\u8f6c\u5411\u4e00\u7cfb\u5217\u65b0\u7684\u836f\u7269\u9776\u70b9\uff0c\u5df2\u7ecf\u4e3a\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u5f00\u8f9f\u4e86\u51e0\u4e2a\u5145\u6ee1\u5e0c\u671b\u7684\u65b9\u5411\u3002\u6709\u4e24\u7c7b\u65b0\u836f\u6839\u672c\u6ca1\u6709\u76f4\u63a5\u7684\u591a\u5df4\u80fa\u6d3b\u6027\uff0c\u800c\u662f\u4f5c\u7528\u4e8e\u5fae\u91cf\u80fa\u548c\u6bd2\u8548\u78b1\u53d7\u4f53\u3002\u5728\u65e9\u671f\u8bd5\u9a8c\u4e2d\uff0c\u8fd9\u4e9b\u836f\u7269\u5df2\u663e\u793a\u51fa\u6cbb\u7597\u66f4\u5e7f\u6cdb\u75c7\u72b6\u7684\u6f5c\u529b\uff0c\u5305\u62ec\u6570\u5341\u5e74\u6765\u591a\u5df4\u80fa\u53d7\u4f53\u963b\u65ad\u5242\u4e00\u76f4\u65e0\u6cd5\u6cbb\u7597\u7684\u9634\u6027\u75c7\u72b6\u548c\u8ba4\u77e5\u75c7\u72b6\u3002<\/p>\n

\u5fae\u91cf\u80fa\u53d7\u4f53 1 (TAAR1) \u6fc0\u52a8\u5242\u3002\u00a0<\/strong>2020 \u5e74\u521d\uff0c\u5728\u5927\u6d41\u884c\u75c5\u7684\u5934\u6761\u65b0\u95fb\u4e2d\uff0c\u4f20\u51fa\u4e86\u4e00\u79cd\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u65b0\u836f\u7269\u7597\u6cd5\u7684\u6d88\u606f\u3002\u5728\u5bfb\u627e\u53ef\u51cf\u8f7b\u52a8\u7269\u6a21\u578b\u7cbe\u795e\u5206\u88c2\u75c7\u75c7\u72b6\u7684\u975e\u591a\u5df4\u80fa\u963b\u65ad\u836f\u7269\u7684\u8fc7\u7a0b\u4e2d\uff0cTAAR1\u6fc0\u52a8\u5242\u8131\u9896\u800c\u51fa\u3002\u5728\u5c0f\u9f20\u4f53\u5185\uff0cTAAR1 \u6fc0\u52a8\u5242\u8fd8\u663e\u793a\u5b83\u4eec\u53ef\u4ee5\u5e2e\u52a9\u66f4\u597d\u5730\u8c03\u8282\u8840\u7cd6\u6c34\u5e73--\u53ef\u80fd\u907f\u514d\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u7684\u4e3b\u8981\u526f\u4f5c\u7528\u4e4b\u4e00\u3002<\/p>\n

\u4e4c\u6d1b\u4ed6\u9686\u662f\u4e00\u79cd TAAR1 \u6fc0\u52a8\u5242\uff0c\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u901a\u8fc7\u963b\u6b62\u8179\u4fa7\u88ab\u76d6\u533a\u7684\u795e\u7ecf\u5143\u53d1\u5c04\u6765\u53d1\u6325\u4f5c\u7528\uff0c\u800c\u8179\u4fa7\u88ab\u76d6\u533a\u662f\u591a\u5df4\u80fa\u6cbf\u7740\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u6709\u5173\u7684\u901a\u8def\u7684\u8d77\u70b9\u3002\u867d\u7136\u8fd9\u79cd\u65b0\u836f\u7684\u4f5c\u7528\u673a\u5236\u4ecd\u7136\u6709\u4e9b\u795e\u79d8\uff0c\u4f46\u5176\u80cc\u540e\u7684\u7406\u5ff5\u5c31\u50cf\u662f\u6251\u706d\u4e86\u70b9\u71c3\u75c7\u72b6\u7684\u706b\u82b1\u3002\u9664\u4e86\u5177\u6709\u5fae\u91cf\u80fa\u6d3b\u6027\u5916\uff0c\u4e4c\u6d1b\u4ed6\u9686\u8fd8\u662f\u795e\u7ecf\u9012\u8d28\u8840\u6e05\u7d20\u7684 5-HT1A \u53d7\u4f53\u6fc0\u52a8\u5242\u3002<\/p>\n

\u5728\u5bf9\u4e00\u9879\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7684\u521d\u6b65\u7ed3\u679c\u8fdb\u884c\u5206\u6790\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e4c\u6d1b\u4ed6\u9686\u5728\u964d\u4f4e PANSS \u603b\u5206\uff08\u8861\u91cf\u7cbe\u795e\u5206\u88c2\u75c7\u75c7\u72b6\u7684\u4e00\u79cd\u7efc\u5408\u6307\u6807\uff09\u65b9\u9762\u7684\u8868\u73b0\u4f18\u4e8e\u5b89\u6170\u5242\u3002\u8fd9\u79cd\u836f\u7269\u8fd8\u80fd\u51cf\u8f7b\u96be\u4ee5\u6cbb\u7597\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u9634\u6027\u75c7\u72b6\uff08\u8fd9\u662f\u4e00\u4e2a\u521d\u6b65\u7ed3\u679c\uff0c\u6ca1\u6709\u5bf9\u8bd5\u9a8c\u6b21\u6570\u8fdb\u884c\u7edf\u8ba1\u8c03\u6574\uff0c\u56e0\u6b64\u6211\u4eec\u65e0\u6cd5\u5f97\u51fa\u80af\u5b9a\u7684\u7ed3\u8bba\uff09\u3002\u9057\u61be\u7684\u662f\uff0c\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0c\u4e24\u9879\u5173\u4e8e\u4e4c\u6d1b\u4ed6\u9f99\u7684 III \u671f\u8bd5\u9a8c\u5747\u627f\u8ba4\uff0c\u4e0e\u670d\u7528\u5b89\u6170\u5242\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7\u4e4c\u6d1b\u4ed6\u9f99\u6cbb\u7597\u7684\u60a3\u8005\u5728 PANSS \u65b9\u9762\u7684\u53cd\u5e94\u5e76\u6ca1\u6709\u660e\u663e\u597d\u8f6c\u3002\u7814\u7a76\u4eba\u5458\u6000\u7591\uff0c\u8fd9\u4e00\u53d1\u73b0\u53ef\u80fd\u4e0e\u8fd9\u4e9b\u7814\u7a76\u4e2d\u5b89\u6170\u5242\u7684\u9ad8\u53cd\u5e94\u7387\u6709\u5173\u3002<\/p>\n

\u53e6\u4e00\u79cd TAAR1 \u836f\u7269\uff0c\u4e00\u79cd\u540d\u4e3a ralmitaront \u7684\u90e8\u5206\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u4e5f\u5728\u7814\u53d1\u4e2d\uff0c\u4f46\u5904\u4e8e\u8f83\u65e9\u9636\u6bb5\u3002ralmitaront \u7684\u4e24\u9879 II \u671f\u8bd5\u9a8c\u5206\u522b\u7814\u7a76\u4e86\u5176\u6cbb\u7597\u9633\u6027\u75c7\u72b6\u548c\u9634\u6027\u75c7\u72b6\u7684\u7597\u6548\uff0c\u4f46\u7531\u4e8e\u8be5\u836f\u7269\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5e76\u4e0d\u80fd\u663e\u8457\u51cf\u8f7b\u75c7\u72b6\uff0c\u56e0\u6b64\u4e24\u9879\u8bd5\u9a8c\u5747\u63d0\u524d\u7ed3\u675f\u3002\u5236\u836f\u516c\u53f8\u662f\u7ee7\u7eed\u5f00\u53d1 TAAR1 \u836f\u7269\uff0c\u8fd8\u662f\u5c06\u8fd9\u4e9b\u559c\u5fe7\u53c2\u534a\u7684\u7ed3\u679c\u4f5c\u4e3a\u505c\u6b62\u5f00\u53d1\u7684\u8ff9\u8c61\uff0c\u8fd9\u8fd8\u662f\u4e00\u4e2a\u672a\u51b3\u95ee\u9898\u3002<\/p>\n

\u6bd2\u8548\u78b1 (M1\/M4) \u6fc0\u52a8\u5242\u3002\u00a0<\/strong>\u5982\u679c\u60a8\u66fe\u7ecf\u670d\u7528\u8fc7\u82ef\u6d77\u62c9\u660e\uff08\u82ef\u6d77\u62c9\u660e\uff09\uff0c\u5e76\u5728\u670d\u7528\u540e\u611f\u89c9\u8ff7\u8ff7\u7cca\u7cca\uff0c\u90a3\u4e48\u60a8\u5c31\u4f1a\u53d1\u73b0\uff0c\u963b\u65ad\u5927\u8111\u4e2d\u7684\u4e59\u9170\u80c6\u78b1\u4f1a\u5bf9\u8ba4\u77e5\u4ea7\u751f\u4e0d\u826f\u5f71\u54cd\u3002\u53cd\u8fc7\u6765\uff0c\u523a\u6fc0\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\u7684\u836f\u7269\u80fd\u5426\u6539\u5584\u8bb0\u5fc6\u5462\uff1f\u8fd9\u5c31\u662f\u4f7f\u7528\u4ecb\u5bfc\u80c6\u78b1\u80fd\u6d3b\u52a8\u7684\u6bd2\u8548\u78b1\u53d7\u4f53\u6fc0\u52a8\u5242\u6765\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u8ba4\u77e5\u75c7\u72b6\u7684\u539f\u7406\u3002<\/p>\n

\u7531\u4e8e\u6bd2\u8548\u78b1\u53d7\u4f53\u6fc0\u52a8\u5242\u53ef\u80fd\u4f1a\u5728\u8111\u5916\u4ea7\u751f\u4e0d\u5fc5\u8981\u7684\u526f\u4f5c\u7528\uff08\u6bd2\u8548\u78b1\u53d7\u4f53\u904d\u5e03\u5168\u8eab\uff0c\u4f5c\u7528\u4e8e\u5927\u591a\u6570\u5668\u5b98\u7cfb\u7edf\uff09\uff0c\u56e0\u6b64\u4e00\u79cd\u7b56\u7565\u662f\u5c06\u6bd2\u8548\u78b1\u53d7\u4f53\u6fc0\u52a8\u5242\u590f\u8bfa\u7f8e\u6797\uff08\u4f5c\u7528\u4e8e\u5168\u8eab\u548c\u5927\u8111\uff09\u4e0e\u6bd2\u8548\u78b1\u62ee\u6297\u5242\u66f2\u53f8\u5339\u6797\u914d\u5bf9\u4f7f\u7528\uff0c\u540e\u8005\u7531\u4e8e\u4e0d\u80fd\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u56e0\u6b64\u4e0d\u4f1a\u5728\u5927\u8111\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u901a\u8fc7\u4ece\u9888\u90e8\u5411\u4e0b\u94fa\u8bbe\u7279\u7f57\u5561\u7bf7\u5e03\uff0c\u8fd9\u79cd\u7ec4\u5408\u4e5f\u6709\u52a9\u4e8e\u786e\u4fdd\u66f4\u591a\u7684\u6c99\u8bfa\u7f8e\u6797\u6d41\u5165\u5927\u8111\u3002\u4e8c\u8005\u4e4b\u95f4\u7684\u5e73\u8861\u4ecd\u5728\u7814\u7a76\u4e4b\u4e2d--\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u5305\u62ec\u4e0e\u80c6\u78b1\u80fd\u6d3b\u6027\u589e\u52a0\u6709\u5173\u7684\u526f\u4f5c\u7528\uff08\u6076\u5fc3\u548c\u5455\u5410\uff09\u548c\u4e0e\u6297\u80c6\u78b1\u80fd\u4f5c\u7528\u6709\u5173\u7684\u526f\u4f5c\u7528\uff08\u4fbf\u79d8\u3001\u53e3\u5e72\u3001\u89c6\u529b\u6a21\u7cca\u548c\u8bb0\u5fc6\u529b\u51cf\u9000\uff09\u3002\u53e6\u4e00\u79cd\u6b63\u5728\u7814\u53d1\u4e2d\u7684\u836f\u7269\u4f9d\u66f2\u9709\u7d20\u4e3b\u8981\u4f5c\u7528\u4e8e 5 \u79cd\u6bd2\u8548\u78b1\u53d7\u4f53\uff08M4\uff09\u4e2d\u7684\u4e00\u79cd\uff0c\u6709\u52a9\u4e8e\u5c06\u5168\u8eab\u526f\u4f5c\u7528\u7684\u98ce\u9669\u964d\u81f3\u6700\u4f4e\uff0c\u540c\u65f6\u4ecd\u80fd\u6539\u5584\u7cbe\u795e\u75c5\u75c7\u72b6\u3002<\/p>\n

\u6709\u5173\u6b63\u5728\u8fdb\u884c\u7684 TAAR1 \u548c\u6bd2\u8548\u78b1\u7c7b\u836f\u7269\u8bd5\u9a8c\u7684\u6700\u65b0\u4fe1\u606f\uff0c\u53ef\u901a\u8fc7\u641c\u7d22\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7ba1\u7406\u7684 clinicaltrials.gov \u7f51\u7ad9\u83b7\u53d6\u3002\u91cd\u8981\u7684\u662f\uff0c\u6211\u4eec\u8981\u4fdd\u6301\u8c28\u614e\u4e50\u89c2\u7684\u6001\u5ea6\uff0c\u8981\u8bb0\u4f4f 20 \u4e16\u7eaa 90 \u5e74\u4ee3\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u7684\u65e9\u671f\u70ed\u6f6e\u662f\u5982\u4f55\u88ab\u4e00\u9879\u66f4\u5927\u89c4\u6a21\u7684\u76f4\u63a5\u6bd4\u8f83\u836f\u7269\u7684\u8bd5\u9a8c\u7ed3\u679c\u6240\u6291\u5236\u7684\u3002\u5c31\u76ee\u524d\u800c\u8a00\uff0c\u503c\u5f97\u5e86\u8d3a\u7684\u662f\uff0c\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u65b0\u673a\u5236\u548c\u65b0\u836f\u7814\u53d1\u53d6\u5f97\u4e86\u521b\u65b0\u6027\u8fdb\u5c55\u3002<\/p>\n

\u53c2\u8003<\/strong><\/p>\n

Abbott, A. (2010).\u7cbe\u795e\u5206\u88c2\u75c7\uff1a\u836f\u7269\u50f5\u5c40\u3002\u00a0\u81ea\u7136<\/em>\u00a0468<\/em><\/strong>, 158-159.<\/p>\n

Brannan, S. K., Sawchak, S., Miller, A. C., Lieberman, J. A., Paul, S. M., & Breier, A. (2021)\u3002\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6bd2\u8548\u78b1\u80c6\u78b1\u80fd\u53d7\u4f53\u6fc0\u52a8\u5242\u548c\u5916\u5468\u62ee\u6297\u5242\u3002\u00a0\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u3001 <\/em>384<\/em><\/strong>, 717-726.<\/p>\n

Goodwin, Kate. (2023).\u7f57\u6c0f\u7ec8\u6b62\u7b2c\u4e8c\u9636\u6bb5\u8bd5\u9a8c\u3002 \u751f\u7269\u7a7a\u95f4<\/em>.<\/p>\n

Koblan, K. S., Kent, J., Hopkins, S. C., Krystal, J. H., Cheng, H., Goldman, R., & Loebel, A. (2020)\u3002\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u975e D2 \u53d7\u4f53\u7ed3\u5408\u836f\u7269\u3002\u00a0\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u3001 <\/em>382<\/em><\/strong>, 1497-1506.<\/p>\n

Lieberman, J. A., Stroub, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., Severe, J., Hsiao, J. K., & the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators.(2005).\u6297\u7cbe\u795e\u75c5\u836f\u7269\u5bf9\u6162\u6027\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u7597\u6548\u3002\u00a0\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff0c353<\/em>(12), 1209-1223.<\/p>\n

Pahwa, M., Sleem, A., Elsayed, O. H., Good, M. E., & El-Mallakh, R. S.<\/em>\u00a0(2021).\u8fc7\u53bb\u5341\u5e74\u7684\u65b0\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u3002\u00a0\u5f53\u524d\u7cbe\u795e\u75c5\u5b66\u62a5\u544a\u300b\u3001<\/em>\u00a023<\/em><\/strong>,1-35.<\/p>\n

\u4f4f\u53cb\u5236\u836f\u682a\u5f0f\u4f1a\u793e\u548c\u5927\u51a2\u5236\u836f\u682a\u5f0f\u4f1a\u793e\uff082023 \u5e74\uff09\u3002\u4f4f\u53cb\u5236\u836f\u548c\u5927\u51a2\u5236\u836f\u5ba3\u5e03\u8bc4\u4f30\u4e4c\u6d1b\u4ed6\u9686\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684 DIAMOND 1 \u548c DIAMOND 2 3 \u671f\u4e34\u5e8a\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u3002 \u4f4f\u53cb\u5236\u836f\u65b0\u95fb\u5ba4\u3002 <\/em><\/p>\n<\/div><\/div><\/div><\/div><\/div>

<\/div><\/div>\n<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4424","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nDrug Discovery for Schizophrenia - CURESZ Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/curesz.org\/zh\/2022-07-01-drug-discovery-for-schizophrenia\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Drug Discovery for Schizophrenia - CURESZ Foundation\" \/>\n<meta property=\"og:url\" content=\"https:\/\/curesz.org\/zh\/2022-07-01-drug-discovery-for-schizophrenia\/\" \/>\n<meta property=\"og:site_name\" content=\"CURESZ Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Cureszorg\/\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-15T19:47:48+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@cureszorg\" \/>\n<meta name=\"twitter:label1\" content=\"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 \u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/curesz.org\\\/2022-07-01-drug-discovery-for-schizophrenia\\\/\",\"url\":\"https:\\\/\\\/curesz.org\\\/2022-07-01-drug-discovery-for-schizophrenia\\\/\",\"name\":\"Drug Discovery for Schizophrenia - CURESZ Foundation\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/curesz.org\\\/#website\"},\"datePublished\":\"2022-06-21T14:26:45+00:00\",\"dateModified\":\"2023-11-15T19:47:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/curesz.org\\\/2022-07-01-drug-discovery-for-schizophrenia\\\/#breadcrumb\"},\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/curesz.org\\\/2022-07-01-drug-discovery-for-schizophrenia\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/curesz.org\\\/2022-07-01-drug-discovery-for-schizophrenia\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/curesz.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Drug Discovery for Schizophrenia\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/curesz.org\\\/#website\",\"url\":\"https:\\\/\\\/curesz.org\\\/\",\"name\":\"CURESZ Foundation\",\"description\":\"The CURESZ Foundation provides educational updates to patients, families, healthcare professionals and the general public about schizophrenia.\",\"publisher\":{\"@id\":\"https:\\\/\\\/curesz.org\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/curesz.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/curesz.org\\\/#organization\",\"name\":\"Curesz Foundation\",\"url\":\"https:\\\/\\\/curesz.org\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\\\/\\\/curesz.org\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/curesz.org\\\/wp-content\\\/uploads\\\/2020\\\/02\\\/cropped-Logo-with-Foundation-Custom.png\",\"contentUrl\":\"https:\\\/\\\/curesz.org\\\/wp-content\\\/uploads\\\/2020\\\/02\\\/cropped-Logo-with-Foundation-Custom.png\",\"width\":200,\"height\":133,\"caption\":\"Curesz Foundation\"},\"image\":{\"@id\":\"https:\\\/\\\/curesz.org\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/Cureszorg\\\/\",\"https:\\\/\\\/x.com\\\/cureszorg\",\"https:\\\/\\\/www.instagram.com\\\/cureszfoundation\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCT3uVzTt8jiJ2qdhuosHPvg\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Drug Discovery for Schizophrenia - CURESZ Foundation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/curesz.org\/zh\/2022-07-01-drug-discovery-for-schizophrenia\/","og_locale":"zh_CN","og_type":"article","og_title":"Drug Discovery for Schizophrenia - CURESZ Foundation","og_url":"https:\/\/curesz.org\/zh\/2022-07-01-drug-discovery-for-schizophrenia\/","og_site_name":"CURESZ Foundation","article_publisher":"https:\/\/www.facebook.com\/Cureszorg\/","article_modified_time":"2023-11-15T19:47:48+00:00","twitter_card":"summary_large_image","twitter_site":"@cureszorg","twitter_misc":{"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4":"7 \u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/curesz.org\/2022-07-01-drug-discovery-for-schizophrenia\/","url":"https:\/\/curesz.org\/2022-07-01-drug-discovery-for-schizophrenia\/","name":"Drug Discovery for Schizophrenia - CURESZ Foundation","isPartOf":{"@id":"https:\/\/curesz.org\/#website"},"datePublished":"2022-06-21T14:26:45+00:00","dateModified":"2023-11-15T19:47:48+00:00","breadcrumb":{"@id":"https:\/\/curesz.org\/2022-07-01-drug-discovery-for-schizophrenia\/#breadcrumb"},"inLanguage":"zh-Hans","potentialAction":[{"@type":"ReadAction","target":["https:\/\/curesz.org\/2022-07-01-drug-discovery-for-schizophrenia\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/curesz.org\/2022-07-01-drug-discovery-for-schizophrenia\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/curesz.org\/"},{"@type":"ListItem","position":2,"name":"Drug Discovery for Schizophrenia"}]},{"@type":"WebSite","@id":"https:\/\/curesz.org\/#website","url":"https:\/\/curesz.org\/","name":"CURESZ\u57fa\u91d1\u4f1a","description":"CURESZ \u57fa\u91d1\u4f1a\u4e3a\u60a3\u8005\u3001\u5bb6\u5ead\u3001\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u4eba\u5458\u548c\u516c\u4f17\u63d0\u4f9b\u6709\u5173\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6559\u80b2\u66f4\u65b0\u3002","publisher":{"@id":"https:\/\/curesz.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/curesz.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-Hans"},{"@type":"Organization","@id":"https:\/\/curesz.org\/#organization","name":"Curesz Foundation","url":"https:\/\/curesz.org\/","logo":{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/curesz.org\/#\/schema\/logo\/image\/","url":"https:\/\/curesz.org\/wp-content\/uploads\/2020\/02\/cropped-Logo-with-Foundation-Custom.png","contentUrl":"https:\/\/curesz.org\/wp-content\/uploads\/2020\/02\/cropped-Logo-with-Foundation-Custom.png","width":200,"height":133,"caption":"Curesz Foundation"},"image":{"@id":"https:\/\/curesz.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/Cureszorg\/","https:\/\/x.com\/cureszorg","https:\/\/www.instagram.com\/cureszfoundation\/","https:\/\/www.youtube.com\/channel\/UCT3uVzTt8jiJ2qdhuosHPvg"]}]}},"_links":{"self":[{"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/pages\/4424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/comments?post=4424"}],"version-history":[{"count":4,"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/pages\/4424\/revisions"}],"predecessor-version":[{"id":5482,"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/pages\/4424\/revisions\/5482"}],"wp:attachment":[{"href":"https:\/\/curesz.org\/zh\/wp-json\/wp\/v2\/media?parent=4424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}