{"id":4772,"date":"2022-12-26T15:47:36","date_gmt":"2022-12-26T15:47:36","guid":{"rendered":"https:\/\/curesz.org\/?page_id=4772"},"modified":"2022-12-26T16:27:10","modified_gmt":"2022-12-26T16:27:10","slug":"targeting-brain-energy-metabolism-changes-in-schizophrenia","status":"publish","type":"page","link":"https:\/\/curesz.org\/zh\/targeting-brain-energy-metabolism-changes-in-schizophrenia\/","title":{"rendered":"\u9488\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u8111\u80fd\u91cf\u4ee3\u8c22\u53d8\u5316"},"content":{"rendered":"

<\/span><\/div>

Brandon Scott Pruett\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb<\/strong><\/p>\n<\/div><\/div><\/div>

\u7cbe\u795e\u5206\u88c2\u75c7\u4e0e\u80fd\u91cf\u4ee3\u8c22\u6539\u53d8\u4e4b\u95f4\u7684\u5173\u8054<\/u><\/p>\n

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\u80fd\u91cf\u4ee3\u8c22\u5bf9\u5927\u8111\u529f\u80fd\u7684\u91cd\u8981\u6027<\/u><\/p>\n

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\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u8111\u80fd\u91cf\u4ee3\u8c22\u53d8\u5316<\/u><\/p>\n

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\u7cbe\u795e\u5206\u88c2\u75c7\u8111\u80fd\u91cf\u4ee3\u8c22\u6539\u53d8\u4e3a\u6f5c\u5728\u6cbb\u7597\u9776\u70b9<\/u><\/p>\n

\u4e00\u4e2a\u7814\u7a76\u8fd9\u4e2a\u95ee\u9898\u7684\u5c0f\u7ec4\u9996\u5148\u786e\u5b9a\u4e86\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u5927\u8111\u80fd\u91cf\u53d8\u5316\uff0c\u7136\u540e\u8bd5\u56fe\u786e\u5b9a\u53ef\u4ee5\u9006\u8f6c\u8fd9\u4e9b\u53d8\u5316\u7684\u836f\u7269\u3002\u4ed6\u4eec\u786e\u5b9a\u7684\u6700\u6709\u5e0c\u671b\u7684\u4e00\u7c7b\u836f\u7269\u5305\u62ec\u5421\u683c\u5217\u916e\uff0c\u8fd9\u662f\u4e00\u79cd FDA \u6279\u51c6\u7684\u836f\u7269\uff0c\u53ef\u4ee5\u589e\u52a0\u4eba\u4f53\u5bf9\u80f0\u5c9b\u7d20\u7684\u654f\u611f\u6027\uff0c\u662f II \u578b\u7cd6\u5c3f\u75c5\u7684\u5e38\u7528\u6cbb\u7597\u65b9\u6cd59<\/sup>.\u7531\u4e8e\u5982\u4e0a\u6240\u8ff0\u80f0\u5c9b\u7d20\u62b5\u6297\u901a\u5e38\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u6709\u5173\uff0c\u56e0\u6b64\u4f7f\u7528\u6b64\u7c7b\u836f\u7269\u53ef\u80fd\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7279\u522b\u6709\u76ca\u3002\u7136\u540e\uff0c\u8be5\u5c0f\u7ec4\u7528\u5421\u683c\u5217\u916e\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u5c0f\u9f20\u6a21\u578b\uff0c\u53d1\u73b0\u5b83\u6539\u5584\u4e86\u8bb0\u5fc6\u529b9<\/sup>.<\/p>\n

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\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/u><\/p>\n

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Brandon Scott Pruett\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u535a\u58eb
\n\u52a9\u7406\u6559\u6388
\n\u7cbe\u795e\u75c5\u5b66\u4e0e\u884c\u4e3a\u795e\u7ecf\u751f\u7269\u5b66\u7cfb
\n\u963f\u62c9\u5df4\u9a6c\u5927\u5b66\u4f2f\u660e\u7ff0 Heersink \u533b\u5b66\u9662<\/p>\n

\u53c2\u8003<\/p>\n

1 \u76ae\u6797\u683c\uff0cT\u3002 \u7b49\u3002<\/em> 18 \u79cd\u6297\u7cbe\u795e\u75c5\u836f\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u4ee3\u8c22\u529f\u80fd\u7684\u6bd4\u8f83\u5f71\u54cd\u3001\u4ee3\u8c22\u5931\u8c03\u7684\u9884\u6d4b\u56e0\u7d20\u4ee5\u53ca\u4e0e\u7cbe\u795e\u75c5\u7406\u5b66\u7684\u5173\u8054\uff1a\u7cfb\u7edf\u56de\u987e\u548c\u7f51\u7edc\u835f\u8403\u5206\u6790\u3002 \u67f3\u53f6\u5200\u7cbe\u795e\u75c5\u5b66<\/em> 7<\/strong>, 64-77, doi:10.1016\/S2215-0366(19)30416-X (2020)\u3002<\/p>\n

2 \u7c73\u5207\u5c14\uff0cAJ \u7b49\u3002<\/em> \u7cbe\u795e\u5206\u88c2\u75c7\u548c\u76f8\u5173\u75be\u75c5\u4e2d\u4ee3\u8c22\u7efc\u5408\u5f81\u548c\u4ee3\u8c22\u5f02\u5e38\u7684\u60a3\u75c5\u7387\u2014\u2014\u7cfb\u7edf\u8bc4\u4ef7\u548c\u835f\u8403\u5206\u6790\u3002 \u516c\u725b<\/em> 39<\/strong>, 306-318, doi:10.1093\/schbul\/sbr148 (2013)\u3002<\/p>\n

3 \u76ae\u6797\u683c\uff0cT\u3002 \u7b49\u3002<\/em> \u9996\u53d1\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u8461\u8404\u7cd6\u7a33\u6001\u53d7\u635f\uff1a\u7cfb\u7edf\u8bc4\u4ef7\u548c\u835f\u8403\u5206\u6790\u3002 \u7f8e\u56fd\u533b\u5b66\u4f1a\u7cbe\u795e\u75c5\u5b66<\/em> 74<\/strong>, 261-269, doi:10.1001\/jamapsychiatry.2016.3803 (2017)\u3002<\/p>\n

4 \u674e Z. \u7b49\u3002<\/em> \u8461\u8404\u7cd6\u548c\u80f0\u5c9b\u7d20\u76f8\u5173\u6027\u72b6\u30012 \u578b\u7cd6\u5c3f\u75c5\u548c\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u98ce\u9669\uff1a\u4e00\u9879\u5b5f\u5fb7\u5c14\u968f\u673a\u7814\u7a76\u3002 \u7535\u5b50\u751f\u7269\u533b\u5b66<\/em> 34<\/strong>, 182-188, doi:10.1016\/j.ebiom.2018.07.037 (2018)\u3002<\/p>\n

5 Pulido, C. \u548c Ryan, TA \u7a81\u89e6\u5c0f\u6ce1\u6c60\u662f\u795e\u7ecf\u672b\u68a2\u7684\u4e3b\u8981\u9690\u6027\u9759\u606f\u4ee3\u8c22\u8d1f\u62c5\u3002 \u79d1\u5b66\u8fdb\u9636<\/em> 7<\/strong>, eabi9027, doi:10.1126\/sciadv.abi9027 (2021)\u3002<\/p>\n

6 Trubetskoy, V. \u7b49\u3002<\/em> \u7ed8\u5236\u57fa\u56e0\u7ec4\u4f4d\u70b9\u6d89\u53ca\u7cbe\u795e\u5206\u88c2\u75c7\u4e2d\u7684\u57fa\u56e0\u548c\u7a81\u89e6\u751f\u7269\u5b66\u3002 \u81ea\u7136<\/em> 604<\/strong>, 502-508, doi:10.1038\/s41586-022-04434-5 (2022)\u3002<\/p>\n

7 Pruett, BS \u548c Meador-Woodruff, JH \u7cbe\u795e\u5206\u88c2\u75c7\u5927\u8111\u4e2d\u80fd\u91cf\u4ee3\u8c22\u6539\u53d8\u3001\u4e73\u9178\u589e\u52a0\u548c pH \u503c\u964d\u4f4e\u7684\u8bc1\u636e\uff1a\u5bf9\u4eba\u7c7b\u5c38\u68c0\u548c\u78c1\u5171\u632f\u6ce2\u8c31\u7814\u7a76\u7684\u91cd\u70b9\u56de\u987e\u548c\u835f\u8403\u5206\u6790\u3002 \u88c2\u53f6\u6c34\u5e93<\/em> 223<\/strong>, 29-42, doi:10.1016\/j.schres.2020.09.003 (2020)\u3002<\/p>\n

8 \u8429\u539f\uff0cH. \u7b49\u3002<\/em> \u964d\u4f4e\u5927\u8111 pH \u503c\u4f5c\u4e3a\u7cbe\u795e\u75be\u75c5\u7684\u5171\u540c\u5185\u8868\u578b\u3002 \u795e\u7ecf\u7cbe\u795e\u836f\u7406\u5b66<\/em> 43<\/strong>, 459-468, doi:10.1038\/npp.2017.167 (2018)\u3002<\/p>\n

9 \u6c99\u5229\u6587\uff0cCR \u7b49\u3002<\/em> \u7cbe\u795e\u5206\u88c2\u75c7\u751f\u7269\u80fd\u91cf\u53d8\u5316\u7684\u8fde\u901a\u6027\u5206\u6790\uff1a\u65b0\u7597\u6cd5\u7684\u9274\u5b9a\u3002 \u5206\u5b50\u795e\u7ecf\u751f\u7269\u5b66<\/em> 56<\/strong>, 4492-4517, doi:10.1007\/s12035-018-1390-4 (2019)\u3002<\/p>\n

10 \u53f2\u5bc6\u65af\uff0cRC \u7b49\u3002<\/em> \u5421\u683c\u5217\u916e\u5bf9\u63a5\u53d7\u6297\u7cbe\u795e\u75c5\u836f\u7269\u6cbb\u7597\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u4ee3\u8c22\u5f02\u5e38\u3001\u7cbe\u795e\u75c5\u7406\u5b66\u548c\u8ba4\u77e5\u529f\u80fd\u7684\u5f71\u54cd\uff1a\u4e00\u9879\u968f\u673a\u53cc\u76f2\u7814\u7a76\u3002 \u88c2\u53f6\u6c34\u5e93<\/em> 143<\/strong>, 18-24, doi:10.1016\/j.schres.2012.10.023 (2013)\u3002<\/p>\n

11 Iranpour, N. \u7b49\u3002<\/em> \u5421\u683c\u5217\u916e\u8f85\u52a9\u6cbb\u7597\u5bf9\u6162\u6027\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u9634\u6027\u75c7\u72b6\u7684\u5f71\u54cd\uff1a\u4e00\u9879\u53cc\u76f2\u548c\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u3002 \u54fc\u54fc\u7cbe\u795e\u836f\u7406\u5b66<\/em> 31<\/strong>, 103-112, doi:10.1002\/hup.2517 (2016)\u3002<\/p>\n

12 Buckley, PF \u548c Stahl, SM \u7cbe\u795e\u5206\u88c2\u75c7\u9634\u6027\u75c7\u72b6\u7684\u836f\u7269\u6cbb\u7597\uff1a\u6cbb\u7597\u673a\u4f1a\u8fd8\u662f\u6b7b\u80e1\u540c\uff1f \u7cbe\u795e\u75c5\u5b66\u62a5<\/em> 115<\/strong>, 93-100, doi:10.1111\/j.1600-0447.2007.00992.x (2007)\u3002<\/p>\n

13 Olfson, M.\u3001Gerhard, T.\u3001Huang, C.\u3001Crystal, S. \u548c Stroup\uff0cTS \u7f8e\u56fd\u7cbe\u795e\u5206\u88c2\u75c7\u6210\u4eba\u7684\u8fc7\u65e9\u6b7b\u4ea1\u3002 \u7f8e\u56fd\u533b\u5b66\u4f1a\u7cbe\u795e\u75c5\u5b66<\/em> 72<\/strong>, 1172-1181, doi:10.1001\/jamapsychiatry.2015.1737 (2015)\u3002<\/p>\n<\/div><\/div><\/div><\/div><\/div>

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